Tuesday, February 26, 2013


Food Allergies and Your Skin 



The skin is a common target organ for allergic responses to food. Acute urticaria is characterized by pruritic, transient, erythematous raised lesions, sometimes accompanied by localized swelling (angioedema). Food allergy accounts for up to 20 percent of cases of acute urticaria and is mediated by IgE specific to food protein. Lesions usually occur within one hour after ingestion of or contact with the causal food. Because only 1.4 percent of cases of chronic or persistent urticaria (i.e., lasting more than six weeks) are caused by food allergy, a search for a causative food in the initial evaluation of this condition is not generally warranted.


Atopic dermatitis usually begins in early infancy and is characterized by a typical distribution (face, scalp and extremities), extreme pruritus and a chronic and relapsing course. This inflammatory skin condition is frequently associated with allergic disorders (e.g., asthma and allergic rhinitis) and with a family history of allergy. Evidence suggests that IgE-mediated food allergy plays a pathogenic role in atopic dermatitis, particularly in children, although non–IgE-mediated food allergy has also been implicated. Clinical studies using double-blind, placebo-controlled food challenges have shown that 37 percent of children with moderate atopic dermatitis have food allergy. By contrast, 6 to 8 percent of infants and children in the general population are allergic to some type of food.   

Dermatitis herpetiformis is a chronic papulovesicular skin disorder in which lesions are distributed over the extensor surfaces of the elbows, knees and buttocks. The disorder is associated with a specific non–IgE-mediated immune sensitivity to gluten (a protein found in wheat, barley, oat and rye). Although dermatitis herpetiformis is related to celiac disease, patients often appear to have no associated gastrointestinal problems. The rash abates with the elimination of gluten from the diet. 

Friday, February 15, 2013

Human Dermal Exposure to Galaxolide from Personal Care Products.

Human Dermal Exposure to Galaxolide from Personal Care Products.

Feb 2013


Laboratório de Engenharia de Processos, Ambiente e Energia, (LEPAE), Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal; Núcleo de Investigação em Farmácia, Centro de Investigação em Saúde e Ambiente (CISA), Escola Superior de Tecnologia da Saúde do Porto/Instituto Politécnico do Porto (ESTSP/IPP), Rua Valente Perfeito, 322, 4400-330, Vila Nova de Gaia, Portugal.


Musks are synthetic fragrances applied on personal care and household products as fixatives, by retarding the release of other fragrances with higher volatility. Galaxolide is the most used polycyclic musk since the 90(th) decade, and it has been detected in several environmental and biological matrices, particularly in human tissues and fluids. For exposure assessment purposes, large monitoring data need to be obtained and rapid but reliable analytical techniques are requested. The main objective of this study is to develop and validate a new and fast analytical methodology to quantify galaxolide in personal careproducts, and to apply this method to real matrices like skin care products (creams and lotions), shower products (soap bar), hair care products (shampoo and hair conditioner) and oral care products (toothpaste), in order to evaluate the human dermal exposure risk. A dispersive solid phase extraction is proposed, using QuEChERS methodology, followed by HPLC with fluorescence detection. Some extraction parameters were studied, like the ratio of sample/solvent amounts, the homogenization time, the salt addition effect and the used sorbents. The validation parameters of the developed method were: a linearity range of 0.005-1.002 mg.kg(-1) sample, a limit of detection of 0.001 mg.kg(-1) sample, repeatability between 0.7 and 11.3% (variation coefficient of six standard injections), an intermediate precision of 2.5% (variation coefficient of six independent analysis of the same sample), mean recoveries ranging from 65% (soap bar) to 95% (body cream), and 3% of global uncertainty in most of the working range. The time of analysis, including the extraction steps, is 60 minutes, allowing a throughput of 4 samples.h(-1) . Galaxolide was detected in all of the seven analyzed products in concentrations ranging from 0.04 ± 0.01 mg.kg(-1) sample (toothpaste) to 280.78 ± 8.19 mg.kg(-1) sample (perfumed body cream), which may correspond to a significant estimated daily human dermal exposure of 904 μg.day(-1) . © 2013 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

Thursday, February 7, 2013

A high-potency, multimechanism skin care regimen provides significant antiaging effects: results from a double-blind, vehicle-controlled clinical trial.

A high-potency, multimechanism skin care regimen provides significant antiaging effects: results from a double-blind, vehicle-controlled clinical trial.

Dec 2012


Skin aging is a multifaceted biological process characterized by the appearance of wrinkles, pigmentation irregularities, and loss of !rmness. These symptoms cannot be fully addressed by any single skin care ingredient or noninvasive cosmetic procedure. A comprehensive treatment approach, including the use of clinically proven topical skin care formulations, provides optimal antiaging effects. A high-strength skin care regimen (NeoStrata® Skin Active; NeoStrata Company, Inc, Princeton, NJ) was developed to deliver a combination of more than 35% active bene!t ingredients, including the......

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